Copper resistant human hepatoblastoma mutant cell lines without metallothionein induction overexpress ATP7B
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چکیده
منابع مشابه
Induction of apoptosis in human tumor cell lines by platelets
Introduction: It has been reported that platelets can eradicate tumor cells in vitro, although the mechanism of this effect has not been determined. The effect of platelets on the induction of apoptosis in tumor cells is largely unknown. Materials and methods: To investigate this effect, two human hematologic cell lines, K562 and Daudi, were independently faced with unstimulated and thromb...
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Human tumor cells lines with acquired resistance to cisplatin (DDP) and carboplatin (CBDCA) are often cross-resistant to copper and vice versa, and some DDP-resistant cells overexpress the copper export pump ATP7B. We sought to demonstrate that ATP7B directly mediates resistance to DDP and CBDCA by stably transfecting human carcinoma cells with a vector designed to express ATP7B. Increased expr...
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Acquired resistance to cisplatin (CDDP) is an issue in cancer chemotherapy. This resistance has been reported to be correlated with the expression of the Cu influx copper transporter 1 (CTR1) and two copper efflux transporters (ATP7A, ATP7B). We investigated the correlation between the expression of these transporters and the sensitivity to CDDP using three pairs of parent cell lines and resist...
متن کاملinduction of apoptosis in human tumor cell lines by platelets
introduction: it has been reported that platelets can eradicate tumor cells in vitro, although the mechanism of this effect has not been determined. the effect of platelets on the induction of apoptosis in tumor cells is largely unknown. materials and methods: to investigate this effect, two human hematologic cell lines, k562 and daudi, were independently faced with unstimulated and thrombin-ac...
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ژورنال
عنوان ژورنال: Hepatology
سال: 1998
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.510280525